nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors

Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.

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Bibliographic Details
Main Authors: Hai-Ying Liang, Zhi-Jin Chen, Hui Xiao, Yu-Hui Lin, Ying-Yi Hu, Lei Chang, Hai-Yin Wu, Peng Wang, Wei Lu, Dong-Ya Zhu, Chun-Xia Luo
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/8f56e6d3aab84052a130814cd8153048
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