nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors

Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.

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Autores principales:	Hai-Ying Liang, Zhi-Jin Chen, Hui Xiao, Yu-Hui Lin, Ying-Yi Hu, Lei Chang, Hai-Yin Wu, Peng Wang, Wei Lu, Dong-Ya Zhu, Chun-Xia Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8f56e6d3aab84052a130814cd8153048
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spelling	oai:doaj.org-article:8f56e6d3aab84052a130814cd81530482021-12-02T16:51:13ZnNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors10.1038/s41467-020-16198-52041-1723https://doaj.org/article/8f56e6d3aab84052a130814cd81530482020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16198-5https://doaj.org/toc/2041-1723Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.Hai-Ying LiangZhi-Jin ChenHui XiaoYu-Hui LinYing-Yi HuLei ChangHai-Yin WuPeng WangWei LuDong-Ya ZhuChun-Xia LuoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hai-Ying Liang Zhi-Jin Chen Hui Xiao Yu-Hui Lin Ying-Yi Hu Lei Chang Hai-Yin Wu Peng Wang Wei Lu Dong-Ya Zhu Chun-Xia Luo nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
description	Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.
format	article
author	Hai-Ying Liang Zhi-Jin Chen Hui Xiao Yu-Hui Lin Ying-Yi Hu Lei Chang Hai-Yin Wu Peng Wang Wei Lu Dong-Ya Zhu Chun-Xia Luo
author_facet	Hai-Ying Liang Zhi-Jin Chen Hui Xiao Yu-Hui Lin Ying-Yi Hu Lei Chang Hai-Yin Wu Peng Wang Wei Lu Dong-Ya Zhu Chun-Xia Luo
author_sort	Hai-Ying Liang
title	nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
title_short	nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
title_full	nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
title_fullStr	nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
title_full_unstemmed	nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
title_sort	nnos-expressing neurons in the vmpfc transform ppvt-derived chronic pain signals into anxiety behaviors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8f56e6d3aab84052a130814cd8153048
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nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors

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