M. tuberculosis sliding β-clamp does not interact directly with the NAD+-dependent DNA ligase.

The sliding β-clamp, an important component of the DNA replication and repair machinery, is drawing increasing attention as a therapeutic target. We report the crystal structure of the M. tuberculosis β-clamp (Mtbβ-clamp) to 3.0 Å resolution. The protein crystallized in the space group C222(1) with...

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Autores principales: Vandna Kukshal, Taran Khanam, Deepti Chopra, Nidhi Singh, Sabyasachi Sanyal, Ravishankar Ramachandran
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/8f920c67fb9b4df8901930b6b7595849
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