M. tuberculosis sliding β-clamp does not interact directly with the NAD+-dependent DNA ligase.
The sliding β-clamp, an important component of the DNA replication and repair machinery, is drawing increasing attention as a therapeutic target. We report the crystal structure of the M. tuberculosis β-clamp (Mtbβ-clamp) to 3.0 Å resolution. The protein crystallized in the space group C222(1) with...
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Autores principales: | Vandna Kukshal, Taran Khanam, Deepti Chopra, Nidhi Singh, Sabyasachi Sanyal, Ravishankar Ramachandran |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/8f920c67fb9b4df8901930b6b7595849 |
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