Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases

Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases

Pim kinases (proviral integration site for Moloney murine leukemia virus kinases) are overexpressed in various types of hematological malignancies and solid carcinomas, and promote cell proliferation and survival. Thus, Pim kinases are validated as targets for antitumor therapy. In this context, our...

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Autores principales: Viet Hung Dao, Isabelle Ourliac-Garnier, Cédric Logé, Florence O. McCarthy, Stéphane Bach, Teresinha Gonçalves da Silva, Caroline Denevault-Sabourin, Jérôme Thiéfaine, Blandine Baratte, Thomas Robert, Fabrice Gouilleux, Marie Brachet-Botineau, Marc-Antoine Bazin, Pascal Marchand
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
cercosporamide
dibenzo[<i>b</i>,<i>d</i>]furan
Pim kinases
CLK1 kinase
kinase inhibitors
anticancer agents
Organic chemistry
QD241-441
Acceso en línea:https://doaj.org/article/8fc82c9ac56046e4ad1322814a4aabf7
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https://doaj.org/article/8fc82c9ac56046e4ad1322814a4aabf7

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