Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases

Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases

Pim kinases (proviral integration site for Moloney murine leukemia virus kinases) are overexpressed in various types of hematological malignancies and solid carcinomas, and promote cell proliferation and survival. Thus, Pim kinases are validated as targets for antitumor therapy. In this context, our...

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Détails bibliographiques
Auteurs principaux: Viet Hung Dao, Isabelle Ourliac-Garnier, Cédric Logé, Florence O. McCarthy, Stéphane Bach, Teresinha Gonçalves da Silva, Caroline Denevault-Sabourin, Jérôme Thiéfaine, Blandine Baratte, Thomas Robert, Fabrice Gouilleux, Marie Brachet-Botineau, Marc-Antoine Bazin, Pascal Marchand
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
cercosporamide
dibenzo[<i>b</i>,<i>d</i>]furan
Pim kinases
CLK1 kinase
kinase inhibitors
anticancer agents
Organic chemistry
QD241-441
Accès en ligne:https://doaj.org/article/8fc82c9ac56046e4ad1322814a4aabf7
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https://doaj.org/article/8fc82c9ac56046e4ad1322814a4aabf7

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