Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions

Small molecule stabilizers of protein–protein interactions hold great therapeutic potential. Based on virtual screening and molecular docking, the authors here develop a strategy to evolve weak, promiscuous inhibitors of 14-3-3 interactions into selective stabilizers of the 14-3-3/ChREBP complex.

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Autores principales:	Eline Sijbesma, Emira Visser, Kathrin Plitzko, Philipp Thiel, Lech-Gustav Milroy, Markus Kaiser, Luc Brunsveld, Christian Ottmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ff8fc48608f42e5b0be3c2e5c15b283
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spelling	oai:doaj.org-article:8ff8fc48608f42e5b0be3c2e5c15b2832021-12-02T18:49:31ZStructure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions10.1038/s41467-020-17741-02041-1723https://doaj.org/article/8ff8fc48608f42e5b0be3c2e5c15b2832020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17741-0https://doaj.org/toc/2041-1723Small molecule stabilizers of protein–protein interactions hold great therapeutic potential. Based on virtual screening and molecular docking, the authors here develop a strategy to evolve weak, promiscuous inhibitors of 14-3-3 interactions into selective stabilizers of the 14-3-3/ChREBP complex.Eline SijbesmaEmira VisserKathrin PlitzkoPhilipp ThielLech-Gustav MilroyMarkus KaiserLuc BrunsveldChristian OttmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eline Sijbesma Emira Visser Kathrin Plitzko Philipp Thiel Lech-Gustav Milroy Markus Kaiser Luc Brunsveld Christian Ottmann Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
description	Small molecule stabilizers of protein–protein interactions hold great therapeutic potential. Based on virtual screening and molecular docking, the authors here develop a strategy to evolve weak, promiscuous inhibitors of 14-3-3 interactions into selective stabilizers of the 14-3-3/ChREBP complex.
format	article
author	Eline Sijbesma Emira Visser Kathrin Plitzko Philipp Thiel Lech-Gustav Milroy Markus Kaiser Luc Brunsveld Christian Ottmann
author_facet	Eline Sijbesma Emira Visser Kathrin Plitzko Philipp Thiel Lech-Gustav Milroy Markus Kaiser Luc Brunsveld Christian Ottmann
author_sort	Eline Sijbesma
title	Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
title_short	Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
title_full	Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
title_fullStr	Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
title_full_unstemmed	Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
title_sort	structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8ff8fc48608f42e5b0be3c2e5c15b283
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Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions

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