Analysis of 11,430 recombinant protein production experiments reveals that protein yield is tunable by synonymous codon changes of translation initiation sites.

Recombinant protein production is a key process in generating proteins of interest in the pharmaceutical industry and biomedical research. However, about 50% of recombinant proteins fail to be expressed in a variety of host cells. Here we show that the accessibility of translation initiation sites m...

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Autores principales: Bikash K Bhandari, Chun Shen Lim, Daniela M Remus, Augustine Chen, Craig van Dolleweerd, Paul P Gardner
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/8ffe8742eb264ab78676a7e11bd5d096
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