ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Following double-strand break a cascade of events leads to the recruitment of repair factors to damaged sites. Here the authors identify ZNF506 as a key factor that mediates post-translational modification changes in H2AX affecting the DNA damage response.

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Autores principales: Somaira Nowsheen, Khaled Aziz, Kuntian Luo, Min Deng, Bo Qin, Jian Yuan, Karthik B. Jeganathan, Jia Yu, Henan Zhang, Wei Ding, Jan M. van Deursen, Zhenkun Lou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
Q
Acceso en línea:https://doaj.org/article/900eef9ab9884019ae8190fe48d02ee3
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https://doaj.org/article/900eef9ab9884019ae8190fe48d02ee3

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