ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

Following double-strand break a cascade of events leads to the recruitment of repair factors to damaged sites. Here the authors identify ZNF506 as a key factor that mediates post-translational modification changes in H2AX affecting the DNA damage response.

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Autores principales:	Somaira Nowsheen, Khaled Aziz, Kuntian Luo, Min Deng, Bo Qin, Jian Yuan, Karthik B. Jeganathan, Jia Yu, Henan Zhang, Wei Ding, Jan M. van Deursen, Zhenkun Lou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/900eef9ab9884019ae8190fe48d02ee3
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spelling	oai:doaj.org-article:900eef9ab9884019ae8190fe48d02ee32021-12-02T17:31:28ZZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage10.1038/s41467-018-05161-02041-1723https://doaj.org/article/900eef9ab9884019ae8190fe48d02ee32018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05161-0https://doaj.org/toc/2041-1723Following double-strand break a cascade of events leads to the recruitment of repair factors to damaged sites. Here the authors identify ZNF506 as a key factor that mediates post-translational modification changes in H2AX affecting the DNA damage response.Somaira NowsheenKhaled AzizKuntian LuoMin DengBo QinJian YuanKarthik B. JeganathanJia YuHenan ZhangWei DingJan M. van DeursenZhenkun LouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Somaira Nowsheen Khaled Aziz Kuntian Luo Min Deng Bo Qin Jian Yuan Karthik B. Jeganathan Jia Yu Henan Zhang Wei Ding Jan M. van Deursen Zhenkun Lou ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
description	Following double-strand break a cascade of events leads to the recruitment of repair factors to damaged sites. Here the authors identify ZNF506 as a key factor that mediates post-translational modification changes in H2AX affecting the DNA damage response.
format	article
author	Somaira Nowsheen Khaled Aziz Kuntian Luo Min Deng Bo Qin Jian Yuan Karthik B. Jeganathan Jia Yu Henan Zhang Wei Ding Jan M. van Deursen Zhenkun Lou
author_facet	Somaira Nowsheen Khaled Aziz Kuntian Luo Min Deng Bo Qin Jian Yuan Karthik B. Jeganathan Jia Yu Henan Zhang Wei Ding Jan M. van Deursen Zhenkun Lou
author_sort	Somaira Nowsheen
title	ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
title_short	ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
title_full	ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
title_fullStr	ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
title_full_unstemmed	ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
title_sort	znf506-dependent positive feedback loop regulates h2ax signaling after dna damage
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/900eef9ab9884019ae8190fe48d02ee3
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ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

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