Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis

The cessation of nephrogenesis determines nephron endowments in mammals. Here the authors show that differential translation of Wnt antagonists versus agonists determines the tipping point from self-renewal to differentiation of nephron progenitors during nephrogenesis, using mutant mice with elevat...

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Autores principales: Alison E. Jarmas, Eric W. Brunskill, Praneet Chaturvedi, Nathan Salomonis, Raphael Kopan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9030b8b26701425f89e53ac2b2eba153
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