Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis

The cessation of nephrogenesis determines nephron endowments in mammals. Here the authors show that differential translation of Wnt antagonists versus agonists determines the tipping point from self-renewal to differentiation of nephron progenitors during nephrogenesis, using mutant mice with elevat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alison E. Jarmas, Eric W. Brunskill, Praneet Chaturvedi, Nathan Salomonis, Raphael Kopan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9030b8b26701425f89e53ac2b2eba153
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9030b8b26701425f89e53ac2b2eba153
record_format	dspace
spelling	oai:doaj.org-article:9030b8b26701425f89e53ac2b2eba1532021-11-08T11:06:46ZProgenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis10.1038/s41467-021-26626-92041-1723https://doaj.org/article/9030b8b26701425f89e53ac2b2eba1532021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26626-9https://doaj.org/toc/2041-1723The cessation of nephrogenesis determines nephron endowments in mammals. Here the authors show that differential translation of Wnt antagonists versus agonists determines the tipping point from self-renewal to differentiation of nephron progenitors during nephrogenesis, using mutant mice with elevated nephron numbers.Alison E. JarmasEric W. BrunskillPraneet ChaturvediNathan SalomonisRaphael KopanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alison E. Jarmas Eric W. Brunskill Praneet Chaturvedi Nathan Salomonis Raphael Kopan Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis
description	The cessation of nephrogenesis determines nephron endowments in mammals. Here the authors show that differential translation of Wnt antagonists versus agonists determines the tipping point from self-renewal to differentiation of nephron progenitors during nephrogenesis, using mutant mice with elevated nephron numbers.
format	article
author	Alison E. Jarmas Eric W. Brunskill Praneet Chaturvedi Nathan Salomonis Raphael Kopan
author_facet	Alison E. Jarmas Eric W. Brunskill Praneet Chaturvedi Nathan Salomonis Raphael Kopan
author_sort	Alison E. Jarmas
title	Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis
title_short	Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis
title_full	Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis
title_fullStr	Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis
title_full_unstemmed	Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis
title_sort	progenitor translatome changes coordinated by tsc1 increase perception of wnt signals to end nephrogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9030b8b26701425f89e53ac2b2eba153
work_keys_str_mv	AT alisonejarmas progenitortranslatomechangescoordinatedbytsc1increaseperceptionofwntsignalstoendnephrogenesis AT ericwbrunskill progenitortranslatomechangescoordinatedbytsc1increaseperceptionofwntsignalstoendnephrogenesis AT praneetchaturvedi progenitortranslatomechangescoordinatedbytsc1increaseperceptionofwntsignalstoendnephrogenesis AT nathansalomonis progenitortranslatomechangescoordinatedbytsc1increaseperceptionofwntsignalstoendnephrogenesis AT raphaelkopan progenitortranslatomechangescoordinatedbytsc1increaseperceptionofwntsignalstoendnephrogenesis
_version_	1718442356889354240

Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis

Ejemplares similares