Glucose and NAADP trigger elementary intracellular β-cell Ca2+ signals

Abstract Pancreatic β-cells release insulin upon a rise in blood glucose. The precise mechanisms of stimulus-secretion coupling, and its failure in Diabetes Mellitus Type 2, remain to be elucidated. The consensus model, as well as a class of currently prescribed anti-diabetic drugs, are based around...

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Autores principales: Paula Maria Heister, Trevor Powell, Antony Galione
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9045c5c0e3dc4eeb89bc5c8eecf10a5d
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