Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF) restrained pathogenic process involving TLR7.

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Detalles Bibliográficos
Autores principales: Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/908466dd2bb34f6fa842dde7cbf2d877
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https://doaj.org/article/908466dd2bb34f6fa842dde7cbf2d877

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