Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF) restrained pathogenic process involving TLR7.

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Autores principales:	Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/908466dd2bb34f6fa842dde7cbf2d877
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spelling	oai:doaj.org-article:908466dd2bb34f6fa842dde7cbf2d8772021-12-02T16:27:51ZAltered function and differentiation of age-associated B cells contribute to the female bias in lupus mice10.1038/s41467-021-25102-82041-1723https://doaj.org/article/908466dd2bb34f6fa842dde7cbf2d8772021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25102-8https://doaj.org/toc/2041-1723Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF) restrained pathogenic process involving TLR7.Edd RickerMichela ManniDanny Flores-CastroDaniel JenkinsSanjay GuptaJuan Rivera-CorreaWenzhao MengAaron M. RosenfeldTania PannelliniMahesh BachuYurii ChinenovPeter K. SculcoRolf JessbergerEline T. Luning PrakAlessandra B. PernisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edd Ricker Michela Manni Danny Flores-Castro Daniel Jenkins Sanjay Gupta Juan Rivera-Correa Wenzhao Meng Aaron M. Rosenfeld Tania Pannellini Mahesh Bachu Yurii Chinenov Peter K. Sculco Rolf Jessberger Eline T. Luning Prak Alessandra B. Pernis Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
description	Autoimmunity mediated by age-associated B cells (ABC) can affect males and females differently. Here, using a lupus-like mouse model that affects females more severely, the authors observe an ABC mediated and guanine nucleotide exchange factor (GEF) restrained pathogenic process involving TLR7.
format	article
author	Edd Ricker Michela Manni Danny Flores-Castro Daniel Jenkins Sanjay Gupta Juan Rivera-Correa Wenzhao Meng Aaron M. Rosenfeld Tania Pannellini Mahesh Bachu Yurii Chinenov Peter K. Sculco Rolf Jessberger Eline T. Luning Prak Alessandra B. Pernis
author_facet	Edd Ricker Michela Manni Danny Flores-Castro Daniel Jenkins Sanjay Gupta Juan Rivera-Correa Wenzhao Meng Aaron M. Rosenfeld Tania Pannellini Mahesh Bachu Yurii Chinenov Peter K. Sculco Rolf Jessberger Eline T. Luning Prak Alessandra B. Pernis
author_sort	Edd Ricker
title	Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
title_short	Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
title_full	Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
title_fullStr	Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
title_full_unstemmed	Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice
title_sort	altered function and differentiation of age-associated b cells contribute to the female bias in lupus mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/908466dd2bb34f6fa842dde7cbf2d877
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Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

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