Characterization and reversal of Doxorubicin-mediated biphasic activation of ERK and persistent excitability in sensory neurons of Aplysia californica

Abstract Doxorubicin (DOX), a common chemotherapeutic agent, impairs synaptic plasticity. DOX also causes a persistent increase in basal neuronal excitability, which occludes serotonin-induced enhanced excitability. Therefore, we sought to characterize and reverse DOX-induced physiological changes a...

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Bibliographic Details
Main Authors: Harini Lakshminarasimhan, Brittany L. Coughlin, Amber S. Darr, John H. Byrne
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
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Online Access:https://doaj.org/article/9085c26eb1104bab9ba19e4f21ed459b
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