Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic mechanism and the molecular basis of LIG4 syn...

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Autores principales: Andrea M. Kaminski, Percy P. Tumbale, Matthew J. Schellenberg, R. Scott Williams, Jason G. Williams, Thomas A. Kunkel, Lars C. Pedersen, Katarzyna Bebenek
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/90b1969015cf4216b1c79319d6b65acc
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