Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic mechanism and the molecular basis of LIG4 syn...

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Autores principales:	Andrea M. Kaminski, Percy P. Tumbale, Matthew J. Schellenberg, R. Scott Williams, Jason G. Williams, Thomas A. Kunkel, Lars C. Pedersen, Katarzyna Bebenek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90b1969015cf4216b1c79319d6b65acc
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spelling	oai:doaj.org-article:90b1969015cf4216b1c79319d6b65acc2021-12-02T14:40:31ZStructures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis10.1038/s41467-018-05024-82041-1723https://doaj.org/article/90b1969015cf4216b1c79319d6b65acc2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05024-8https://doaj.org/toc/2041-1723DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic mechanism and the molecular basis of LIG4 syndrome causing disease mutations.Andrea M. KaminskiPercy P. TumbaleMatthew J. SchellenbergR. Scott WilliamsJason G. WilliamsThomas A. KunkelLars C. PedersenKatarzyna BebenekNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrea M. Kaminski Percy P. Tumbale Matthew J. Schellenberg R. Scott Williams Jason G. Williams Thomas A. Kunkel Lars C. Pedersen Katarzyna Bebenek Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis
description	DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic mechanism and the molecular basis of LIG4 syndrome causing disease mutations.
format	article
author	Andrea M. Kaminski Percy P. Tumbale Matthew J. Schellenberg R. Scott Williams Jason G. Williams Thomas A. Kunkel Lars C. Pedersen Katarzyna Bebenek
author_facet	Andrea M. Kaminski Percy P. Tumbale Matthew J. Schellenberg R. Scott Williams Jason G. Williams Thomas A. Kunkel Lars C. Pedersen Katarzyna Bebenek
author_sort	Andrea M. Kaminski
title	Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis
title_short	Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis
title_full	Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis
title_fullStr	Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis
title_full_unstemmed	Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis
title_sort	structures of dna-bound human ligase iv catalytic core reveal insights into substrate binding and catalysis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/90b1969015cf4216b1c79319d6b65acc
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Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

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