Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity

The human shelterin complex protects telomere ends from being recognized as damaged DNA sites and regulates telomere length in conjunction with telomerase. Here the authors establish the stoichiometries of human shelterin complexes of various compositions and show shelterin provides dual pathways to...

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Bibliographic Details
Main Authors: Ci Ji Lim, Arthur J. Zaug, Hee Jin Kim, Thomas R. Cech
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/90c4dc3412f446f394369937d6da4c33
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