In vitro ribosome synthesis and evolution through ribosome display

Directed evolution of the ribosome is challenging because the requirement of cell viability limits the mutations that can be made. Here the authors develop a platform for in vitro ribosome synthesis and evolution (RISE) to overcome these constraints.

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Autores principales:	Michael J. Hammerling, Brian R. Fritz, Danielle J. Yoesep, Do Soon Kim, Erik D. Carlson, Michael C. Jewett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/90c6cf26ca364bed8ba59a292847a428
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spelling	oai:doaj.org-article:90c6cf26ca364bed8ba59a292847a4282021-12-02T15:37:20ZIn vitro ribosome synthesis and evolution through ribosome display10.1038/s41467-020-14705-22041-1723https://doaj.org/article/90c6cf26ca364bed8ba59a292847a4282020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14705-2https://doaj.org/toc/2041-1723Directed evolution of the ribosome is challenging because the requirement of cell viability limits the mutations that can be made. Here the authors develop a platform for in vitro ribosome synthesis and evolution (RISE) to overcome these constraints.Michael J. HammerlingBrian R. FritzDanielle J. YoesepDo Soon KimErik D. CarlsonMichael C. JewettNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael J. Hammerling Brian R. Fritz Danielle J. Yoesep Do Soon Kim Erik D. Carlson Michael C. Jewett In vitro ribosome synthesis and evolution through ribosome display
description	Directed evolution of the ribosome is challenging because the requirement of cell viability limits the mutations that can be made. Here the authors develop a platform for in vitro ribosome synthesis and evolution (RISE) to overcome these constraints.
format	article
author	Michael J. Hammerling Brian R. Fritz Danielle J. Yoesep Do Soon Kim Erik D. Carlson Michael C. Jewett
author_facet	Michael J. Hammerling Brian R. Fritz Danielle J. Yoesep Do Soon Kim Erik D. Carlson Michael C. Jewett
author_sort	Michael J. Hammerling
title	In vitro ribosome synthesis and evolution through ribosome display
title_short	In vitro ribosome synthesis and evolution through ribosome display
title_full	In vitro ribosome synthesis and evolution through ribosome display
title_fullStr	In vitro ribosome synthesis and evolution through ribosome display
title_full_unstemmed	In vitro ribosome synthesis and evolution through ribosome display
title_sort	in vitro ribosome synthesis and evolution through ribosome display
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/90c6cf26ca364bed8ba59a292847a428
work_keys_str_mv	AT michaeljhammerling invitroribosomesynthesisandevolutionthroughribosomedisplay AT brianrfritz invitroribosomesynthesisandevolutionthroughribosomedisplay AT daniellejyoesep invitroribosomesynthesisandevolutionthroughribosomedisplay AT dosoonkim invitroribosomesynthesisandevolutionthroughribosomedisplay AT erikdcarlson invitroribosomesynthesisandevolutionthroughribosomedisplay AT michaelcjewett invitroribosomesynthesisandevolutionthroughribosomedisplay
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In vitro ribosome synthesis and evolution through ribosome display

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