Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA

Abstract α-Conotoxins are small disulfide-rich peptides targeting nicotinic acetylcholine receptors (nAChRs) characterised by a CICII-Xm-CIII-Xn-CIV framework that invariably adopt the native globular conformations which is typically most potent. α-Conotoxins are divided into several structural subg...

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Autores principales: Thao N. T. Ho, Nikita Abraham, Richard J. Lewis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/90cdf3a5ccdd43e1b090a6de1b268a4b
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