Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA
Abstract α-Conotoxins are small disulfide-rich peptides targeting nicotinic acetylcholine receptors (nAChRs) characterised by a CICII-Xm-CIII-Xn-CIV framework that invariably adopt the native globular conformations which is typically most potent. α-Conotoxins are divided into several structural subg...
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Formato: | article |
Lenguaje: | EN |
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Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/90cdf3a5ccdd43e1b090a6de1b268a4b |
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