Ultrafast enzymatic digestion of proteins by microdroplet mass spectrometry

Mass spectrometry (MS)-based protein sequencing usually relies on in-solution proteolytic digestion, which is time-consuming and inefficient for certain proteins. Here, the authors achieve full protein sequence coverage in less than 1 ms by subjecting protein-protease mixtures to electrosonic spray...

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Autores principales: Xiaoqin Zhong, Hao Chen, Richard N. Zare
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/9103b196c210493f84d133ce107df39f
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