p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability

p50 is a constitutively produced NF-κB subunit that modulates the response to DNA damage. Here, the authors show that activation of ATR during S phase induces p50 interaction with BARD1 resulting in p50 mono-ubiquitination, facilitating cell cycle progression and promoting chromosome integrity.

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Autores principales:	Longtao Wu, Clayton D. Crawley, Andrea Garofalo, Jackie W. Nichols, Paige-Ashley Campbell, Galina F. Khramtsova, Olufunmilayo I. Olopade, Ralph R. Weichselbaum, Bakhtiar Yamini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/910a2213640443158f5902af774dca02
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spelling	oai:doaj.org-article:910a2213640443158f5902af774dca022021-12-02T18:37:29Zp50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability10.1038/s41467-020-18838-22041-1723https://doaj.org/article/910a2213640443158f5902af774dca022020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18838-2https://doaj.org/toc/2041-1723p50 is a constitutively produced NF-κB subunit that modulates the response to DNA damage. Here, the authors show that activation of ATR during S phase induces p50 interaction with BARD1 resulting in p50 mono-ubiquitination, facilitating cell cycle progression and promoting chromosome integrity.Longtao WuClayton D. CrawleyAndrea GarofaloJackie W. NicholsPaige-Ashley CampbellGalina F. KhramtsovaOlufunmilayo I. OlopadeRalph R. WeichselbaumBakhtiar YaminiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Longtao Wu Clayton D. Crawley Andrea Garofalo Jackie W. Nichols Paige-Ashley Campbell Galina F. Khramtsova Olufunmilayo I. Olopade Ralph R. Weichselbaum Bakhtiar Yamini p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability
description	p50 is a constitutively produced NF-κB subunit that modulates the response to DNA damage. Here, the authors show that activation of ATR during S phase induces p50 interaction with BARD1 resulting in p50 mono-ubiquitination, facilitating cell cycle progression and promoting chromosome integrity.
format	article
author	Longtao Wu Clayton D. Crawley Andrea Garofalo Jackie W. Nichols Paige-Ashley Campbell Galina F. Khramtsova Olufunmilayo I. Olopade Ralph R. Weichselbaum Bakhtiar Yamini
author_facet	Longtao Wu Clayton D. Crawley Andrea Garofalo Jackie W. Nichols Paige-Ashley Campbell Galina F. Khramtsova Olufunmilayo I. Olopade Ralph R. Weichselbaum Bakhtiar Yamini
author_sort	Longtao Wu
title	p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability
title_short	p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability
title_full	p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability
title_fullStr	p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability
title_full_unstemmed	p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability
title_sort	p50 mono-ubiquitination and interaction with bard1 regulates cell cycle progression and maintains genome stability
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/910a2213640443158f5902af774dca02
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p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability

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