Lack of AcrB Efflux Function Confers Loss of Virulence on <italic toggle="yes">Salmonella enterica</italic> Serovar Typhimurium

ABSTRACT AcrAB-TolC is the paradigm resistance-nodulation-division (RND) multidrug resistance efflux system in Gram-negative bacteria, with AcrB being the pump protein in this complex. We constructed a nonfunctional AcrB mutant by replacing D408, a highly conserved residue essential for proton trans...

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Autores principales:	Xuan Wang-Kan, Jessica M. A. Blair, Barbara Chirullo, Jonathan Betts, Roberto M. La Ragione, Alasdair Ivens, Vito Ricci, Timothy J. Opperman, Laura J. V. Piddock
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	AcrB SPI Salmonella Salmonella pathogenicity island efflux motility Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/91114a33f62a45c7933725d7402ec642
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Lack of AcrB Efflux Function Confers Loss of Virulence on <italic toggle="yes">Salmonella enterica</italic> Serovar Typhimurium

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