Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance

Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance

ABSTRACT Daptomycin, a calcium-dependent lipopeptide antibiotic whose full mode of action is still not entirely understood, has become a standard-of-care agent for treating methicillin-resistant Staphylococcus aureus (MRSA) infections. Daptomycin-resistant (DAP-R) S. aureus mutants emerge during the...

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Autores principales: Christoph M. Ernst, Christoph J. Slavetinsky, Sebastian Kuhn, Janna N. Hauser, Mulugeta Nega, Nagendra N. Mishra, Cordula Gekeler, Arnold S. Bayer, Andreas Peschel
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
daptomycin
MRSA
MprF
Staphylococcus aureus
antibiotic resistance
flippase
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/91185988fd2b4f0eadcc6a36be94023e
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