Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice

During the progression of type 2 diabetes, insulin-producing β-cells can lose their identity and become reprogrammed into other cell types. Here the authors show that murine diabetic β-cells require the protein Raptor for maintaining β-cell health and preventing them from turning into α-cells, indep...

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Main Authors:	Qinglei Yin, Qicheng Ni, Yichen Wang, Hongli Zhang, Wenyi Li, Aifang Nie, Shu Wang, Yanyun Gu, Qidi Wang, Guang Ning
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/912693f29da74215989426c806a40972
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spelling	oai:doaj.org-article:912693f29da74215989426c806a409722021-12-02T15:45:13ZRaptor determines β-cell identity and plasticity independent of hyperglycemia in mice10.1038/s41467-020-15935-02041-1723https://doaj.org/article/912693f29da74215989426c806a409722020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15935-0https://doaj.org/toc/2041-1723During the progression of type 2 diabetes, insulin-producing β-cells can lose their identity and become reprogrammed into other cell types. Here the authors show that murine diabetic β-cells require the protein Raptor for maintaining β-cell health and preventing them from turning into α-cells, independent of Raptor’s involvement in regulating blood sugar levels.Qinglei YinQicheng NiYichen WangHongli ZhangWenyi LiAifang NieShu WangYanyun GuQidi WangGuang NingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qinglei Yin Qicheng Ni Yichen Wang Hongli Zhang Wenyi Li Aifang Nie Shu Wang Yanyun Gu Qidi Wang Guang Ning Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
description	During the progression of type 2 diabetes, insulin-producing β-cells can lose their identity and become reprogrammed into other cell types. Here the authors show that murine diabetic β-cells require the protein Raptor for maintaining β-cell health and preventing them from turning into α-cells, independent of Raptor’s involvement in regulating blood sugar levels.
format	article
author	Qinglei Yin Qicheng Ni Yichen Wang Hongli Zhang Wenyi Li Aifang Nie Shu Wang Yanyun Gu Qidi Wang Guang Ning
author_facet	Qinglei Yin Qicheng Ni Yichen Wang Hongli Zhang Wenyi Li Aifang Nie Shu Wang Yanyun Gu Qidi Wang Guang Ning
author_sort	Qinglei Yin
title	Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
title_short	Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
title_full	Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
title_fullStr	Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
title_full_unstemmed	Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
title_sort	raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/912693f29da74215989426c806a40972
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Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice

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