Outer-membrane-acting peptides and lipid II-targeting antibiotics cooperatively kill Gram-negative pathogens

Li, Cebrian et al. show that a combination of peptide D-11 and vancomycin exhibits a potent antimicrobial activity against a panel of Gram-negative pathogens without apparent toxicity. They find that this combination is also effective in clearing Pseudomonas aeruginosa in mice, providing a potential...

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Bibliographic Details
Main Authors: Qian Li, Rubén Cebrián, Manuel Montalbán-López, Huan Ren, Weihui Wu, Oscar P. Kuipers
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Online Access:https://doaj.org/article/912c6d829b084385a8edefa3d512316c
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