Opioid antagonism modulates wanting-related frontostriatal connectivity

Theoretical accounts distinguish between motivational (‘wanting’) and hedonic (‘liking’) dimensions of rewards. Previous animal and human research linked wanting and liking to anatomically and neurochemically distinct brain mechanisms, but it remains unknown how the different brain regions and neuro...

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Auteurs principaux:	Alexander Soutschek, Susanna C Weber, Thorsten Kahnt, Boris B Quednow, Philippe N Tobler
Format:	article
Langue:	EN
Publié:	eLife Sciences Publications Ltd 2021
Sujets:	reward wanting liking dopamine opioid striatum Medicine R Science Q Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/9143a00e692047219605e71da4ab7cc1
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id	oai:doaj.org-article:9143a00e692047219605e71da4ab7cc1
record_format	dspace
spelling	oai:doaj.org-article:9143a00e692047219605e71da4ab7cc12021-11-17T08:41:32ZOpioid antagonism modulates wanting-related frontostriatal connectivity10.7554/eLife.710772050-084Xe71077https://doaj.org/article/9143a00e692047219605e71da4ab7cc12021-11-01T00:00:00Zhttps://elifesciences.org/articles/71077https://doaj.org/toc/2050-084XTheoretical accounts distinguish between motivational (‘wanting’) and hedonic (‘liking’) dimensions of rewards. Previous animal and human research linked wanting and liking to anatomically and neurochemically distinct brain mechanisms, but it remains unknown how the different brain regions and neurotransmitter systems interact in processing distinct reward dimensions. Here, we assessed how pharmacological manipulations of opioid and dopamine receptor activation modulate the neural processing of wanting and liking in humans in a randomized, placebo-controlled, double-blind clinical trial. Reducing opioid receptor activation with naltrexone selectively reduced wanting of rewards, which on a neural level was reflected by stronger coupling between dorsolateral prefrontal cortex and the striatum under naltrexone compared with placebo. In contrast, reducing dopaminergic neurotransmission with amisulpride revealed no robust effects on behavior or neural activity. Our findings thus provide insights into how opioid receptors mediate neural connectivity related to specifically motivational, not hedonic, aspects of rewards.Alexander SoutschekSusanna C WeberThorsten KahntBoris B QuednowPhilippe N ToblereLife Sciences Publications LtdarticlerewardwantinglikingdopamineopioidstriatumMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	reward wanting liking dopamine opioid striatum Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	reward wanting liking dopamine opioid striatum Medicine R Science Q Biology (General) QH301-705.5 Alexander Soutschek Susanna C Weber Thorsten Kahnt Boris B Quednow Philippe N Tobler Opioid antagonism modulates wanting-related frontostriatal connectivity
description	Theoretical accounts distinguish between motivational (‘wanting’) and hedonic (‘liking’) dimensions of rewards. Previous animal and human research linked wanting and liking to anatomically and neurochemically distinct brain mechanisms, but it remains unknown how the different brain regions and neurotransmitter systems interact in processing distinct reward dimensions. Here, we assessed how pharmacological manipulations of opioid and dopamine receptor activation modulate the neural processing of wanting and liking in humans in a randomized, placebo-controlled, double-blind clinical trial. Reducing opioid receptor activation with naltrexone selectively reduced wanting of rewards, which on a neural level was reflected by stronger coupling between dorsolateral prefrontal cortex and the striatum under naltrexone compared with placebo. In contrast, reducing dopaminergic neurotransmission with amisulpride revealed no robust effects on behavior or neural activity. Our findings thus provide insights into how opioid receptors mediate neural connectivity related to specifically motivational, not hedonic, aspects of rewards.
format	article
author	Alexander Soutschek Susanna C Weber Thorsten Kahnt Boris B Quednow Philippe N Tobler
author_facet	Alexander Soutschek Susanna C Weber Thorsten Kahnt Boris B Quednow Philippe N Tobler
author_sort	Alexander Soutschek
title	Opioid antagonism modulates wanting-related frontostriatal connectivity
title_short	Opioid antagonism modulates wanting-related frontostriatal connectivity
title_full	Opioid antagonism modulates wanting-related frontostriatal connectivity
title_fullStr	Opioid antagonism modulates wanting-related frontostriatal connectivity
title_full_unstemmed	Opioid antagonism modulates wanting-related frontostriatal connectivity
title_sort	opioid antagonism modulates wanting-related frontostriatal connectivity
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/9143a00e692047219605e71da4ab7cc1
work_keys_str_mv	AT alexandersoutschek opioidantagonismmodulateswantingrelatedfrontostriatalconnectivity AT susannacweber opioidantagonismmodulateswantingrelatedfrontostriatalconnectivity AT thorstenkahnt opioidantagonismmodulateswantingrelatedfrontostriatalconnectivity AT borisbquednow opioidantagonismmodulateswantingrelatedfrontostriatalconnectivity AT philippentobler opioidantagonismmodulateswantingrelatedfrontostriatalconnectivity
_version_	1718425683975208960

Opioid antagonism modulates wanting-related frontostriatal connectivity

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