Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B

Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B

Two of the main pathologies characterizing dysferlinopathies are disrupted muscle membrane repair and chronic inflammation, which lead to symptoms of muscle weakness and wasting. Here, we used recombinant human Galectin-1 (rHsGal-1) as a therapeutic for LGMD2B mouse and human models. Various redox a...

Full description

Saved in:
Bibliographic Details
Main Authors: Mary L. Vallecillo-Zúniga, Peter Daniel Poulson, Jacob S. Luddington, Christian J. Arnold, Matthew Rathgeber, Braden C. Kartchner, Spencer Hayes, Hailie Gill, Jonard C. Valdoz, Jonathan L. Spallino, Seth Garfield, Ethan L. Dodson, Connie M. Arthur, Sean R. Stowell, Pam M. Van Ry
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
Galectin-1
LGMD2B
membrane repair
NF-ĸB
inflammation
cytokines
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/91776f7c4f7e4124ac9a89b01315ee53
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/91776f7c4f7e4124ac9a89b01315ee53

Similar Items