Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons

Here, the authors perform ATAC-seq on four distinct cell populations from three different regions of the human brain, finding that chromatin accessibility varies greatly by cell type and less by brain region. This study reveals differences in biological function and gene regulation, as well as overl...

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Autores principales:	Mads E. Hauberg, Jordi Creus-Muncunill, Jaroslav Bendl, Alexey Kozlenkov, Biao Zeng, Chuhyon Corwin, Sarah Chowdhury, Harald Kranz, Yasmin L. Hurd, Michael Wegner, Anders D. Børglum, Stella Dracheva, Michelle E. Ehrlich, John F. Fullard, Panos Roussos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/91a74a493df14309930cea9170546613
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spelling	oai:doaj.org-article:91a74a493df14309930cea91705466132021-12-02T14:40:40ZCommon schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons10.1038/s41467-020-19319-22041-1723https://doaj.org/article/91a74a493df14309930cea91705466132020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19319-2https://doaj.org/toc/2041-1723Here, the authors perform ATAC-seq on four distinct cell populations from three different regions of the human brain, finding that chromatin accessibility varies greatly by cell type and less by brain region. This study reveals differences in biological function and gene regulation, as well as overlap of genetic variants associated with schizophrenia and other neuropsychiatric traits.Mads E. HaubergJordi Creus-MuncunillJaroslav BendlAlexey KozlenkovBiao ZengChuhyon CorwinSarah ChowdhuryHarald KranzYasmin L. HurdMichael WegnerAnders D. BørglumStella DrachevaMichelle E. EhrlichJohn F. FullardPanos RoussosNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mads E. Hauberg Jordi Creus-Muncunill Jaroslav Bendl Alexey Kozlenkov Biao Zeng Chuhyon Corwin Sarah Chowdhury Harald Kranz Yasmin L. Hurd Michael Wegner Anders D. Børglum Stella Dracheva Michelle E. Ehrlich John F. Fullard Panos Roussos Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
description	Here, the authors perform ATAC-seq on four distinct cell populations from three different regions of the human brain, finding that chromatin accessibility varies greatly by cell type and less by brain region. This study reveals differences in biological function and gene regulation, as well as overlap of genetic variants associated with schizophrenia and other neuropsychiatric traits.
format	article
author	Mads E. Hauberg Jordi Creus-Muncunill Jaroslav Bendl Alexey Kozlenkov Biao Zeng Chuhyon Corwin Sarah Chowdhury Harald Kranz Yasmin L. Hurd Michael Wegner Anders D. Børglum Stella Dracheva Michelle E. Ehrlich John F. Fullard Panos Roussos
author_facet	Mads E. Hauberg Jordi Creus-Muncunill Jaroslav Bendl Alexey Kozlenkov Biao Zeng Chuhyon Corwin Sarah Chowdhury Harald Kranz Yasmin L. Hurd Michael Wegner Anders D. Børglum Stella Dracheva Michelle E. Ehrlich John F. Fullard Panos Roussos
author_sort	Mads E. Hauberg
title	Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
title_short	Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
title_full	Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
title_fullStr	Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
title_full_unstemmed	Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
title_sort	common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/91a74a493df14309930cea9170546613
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Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons

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