CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for <italic toggle="yes">var2csa</italic> Gene Activation or Silencing in <italic toggle="yes">Plasmodium falciparum</italic>

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CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for <italic toggle="yes">var2csa</italic> Gene Activation or Silencing in <italic toggle="yes">Plasmodium falciparum</italic>

ABSTRACT Plasmodium falciparum relies on monoallelic expression of 1 of 60 var virulence genes for antigenic variation and host immune evasion. Each var gene contains a conserved intron which has been implicated in previous studies in both activation and repression of transcription via several epige...

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Auteurs principaux:	Jessica M. Bryant, Clément Regnault, Christine Scheidig-Benatar, Sebastian Baumgarten, Julien Guizetti, Artur Scherf
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2017
Sujets:	CRISPR/Cas9 Plasmodium falciparum antigenic variation transcriptional regulation var genes Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/91d89e87606c4bb78714e1eb9743529d
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