CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for <italic toggle="yes">var2csa</italic> Gene Activation or Silencing in <italic toggle="yes">Plasmodium falciparum</italic>

CRISPR/Cas9 Genome Editing Reveals That the Intron Is Not Essential for <italic toggle="yes">var2csa</italic> Gene Activation or Silencing in <italic toggle="yes">Plasmodium falciparum</italic>

ABSTRACT Plasmodium falciparum relies on monoallelic expression of 1 of 60 var virulence genes for antigenic variation and host immune evasion. Each var gene contains a conserved intron which has been implicated in previous studies in both activation and repression of transcription via several epige...

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Bibliographic Details
Main Authors: Jessica M. Bryant, Clément Regnault, Christine Scheidig-Benatar, Sebastian Baumgarten, Julien Guizetti, Artur Scherf
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
CRISPR/Cas9
Plasmodium falciparum
antigenic variation
transcriptional regulation
var genes
Microbiology
QR1-502
Online Access:https://doaj.org/article/91d89e87606c4bb78714e1eb9743529d
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