In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases

In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases

Abstract Background Preclinical and pathology evidence suggests an involvement of brain dopamine (DA) circuitry in Alzheimer’s disease (AD). We in vivo investigated if, when, and in which target regions [123I]FP-CIT-SPECT regional binding and molecular connectivity are damaged along the AD course. M...

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Autores principales: Arianna Sala, Silvia Paola Caminiti, Luca Presotto, Andrea Pilotto, Claudio Liguori, Agostino Chiaravalloti, Valentina Garibotto, Giovanni Battista Frisoni, Marcello D’Amelio, Barbara Paghera, Orazio Schillaci, Nicola Mercuri, Alessandro Padovani, Daniela Perani
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Biomarker
Dopamine
Molecular connectivity
Substantia nigra
Ventral tegmental area
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/921d49dd07834f4fb2a6a1ada03cfd92
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https://doaj.org/article/921d49dd07834f4fb2a6a1ada03cfd92

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