Chronic increase of urea leads to carbamylated proteins accumulation in tissues in a mouse model of CKD.

Carbamylation is a general process involved in protein molecular ageing due to the nonenzymatic binding of isocyanic acid, mainly generated by urea dissociation, to free amino groups. In vitro experiments and clinical studies have suggested the potential involvement of carbamylated proteins (CPs) in...

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Autores principales: Christine Pietrement, Laëtitia Gorisse, Stéphane Jaisson, Philippe Gillery
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/9222d320f34d4b7c831552cff51fa7bf
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