Functional characterization of MODY2 mutations highlights the importance of the fine-tuning of glucokinase and its role in glucose sensing.

Glucokinase (GK) acts as a glucose sensor in the pancreatic beta-cell and regulates insulin secretion. Heterozygous mutations in the human GK-encoding GCK gene that reduce the activity index increase the glucose-stimulated insulin secretion threshold and cause familial, mild fasting hyperglycaemia,...

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Autores principales: Carmen-María García-Herrero, Oscar Rubio-Cabezas, Sharona Azriel, Angel Gutierrez-Nogués, Angel Aragonés, Olivier Vincent, Angel Campos-Barros, Jesús Argente, María-Angeles Navas
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/922a1fa58b42429c864ff12388c797d1
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