Comprehensive analysis of normal adjacent to tumor transcriptomes

Normal tissue adjacent to the tumour (NAT) is often used as a control in cancer studies. Here, the authors analyse across cancer types the transcriptomes of healthy, NAT, and tumour tissues, and find that NAT presents a unique state, potentially due to inflammatory response of the NAT to the tumour...

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Autores principales: Dvir Aran, Roman Camarda, Justin Odegaard, Hyojung Paik, Boris Oskotsky, Gregor Krings, Andrei Goga, Marina Sirota, Atul J. Butte
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/92442fbf71dc46038ab5ef9c6bf555db
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Sumario:Normal tissue adjacent to the tumour (NAT) is often used as a control in cancer studies. Here, the authors analyse across cancer types the transcriptomes of healthy, NAT, and tumour tissues, and find that NAT presents a unique state, potentially due to inflammatory response of the NAT to the tumour tissue.