Designing an irreversible metabolic switch for scalable induction of microbial chemical production

A promising strategy to increase product synthesis from bacteria uses inducible systems to switch metabolism to production. Here, the authors use models to show how engineering positive feedback loops into the genetic circuitry creates a switch that requires only temporary induction with a cheap nut...

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Detalles Bibliográficos
Autores principales:	Ahmad A. Mannan, Declan G. Bates
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/925f3bab049a46a39d8569145e04adbe
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spelling	oai:doaj.org-article:925f3bab049a46a39d8569145e04adbe2021-12-02T15:02:50ZDesigning an irreversible metabolic switch for scalable induction of microbial chemical production10.1038/s41467-021-23606-x2041-1723https://doaj.org/article/925f3bab049a46a39d8569145e04adbe2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23606-xhttps://doaj.org/toc/2041-1723A promising strategy to increase product synthesis from bacteria uses inducible systems to switch metabolism to production. Here, the authors use models to show how engineering positive feedback loops into the genetic circuitry creates a switch that requires only temporary induction with a cheap nutrient to switch metabolism irreversibly, and so drastically reduce inducer use and cost.Ahmad A. MannanDeclan G. BatesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ahmad A. Mannan Declan G. Bates Designing an irreversible metabolic switch for scalable induction of microbial chemical production
description	A promising strategy to increase product synthesis from bacteria uses inducible systems to switch metabolism to production. Here, the authors use models to show how engineering positive feedback loops into the genetic circuitry creates a switch that requires only temporary induction with a cheap nutrient to switch metabolism irreversibly, and so drastically reduce inducer use and cost.
format	article
author	Ahmad A. Mannan Declan G. Bates
author_facet	Ahmad A. Mannan Declan G. Bates
author_sort	Ahmad A. Mannan
title	Designing an irreversible metabolic switch for scalable induction of microbial chemical production
title_short	Designing an irreversible metabolic switch for scalable induction of microbial chemical production
title_full	Designing an irreversible metabolic switch for scalable induction of microbial chemical production
title_fullStr	Designing an irreversible metabolic switch for scalable induction of microbial chemical production
title_full_unstemmed	Designing an irreversible metabolic switch for scalable induction of microbial chemical production
title_sort	designing an irreversible metabolic switch for scalable induction of microbial chemical production
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/925f3bab049a46a39d8569145e04adbe
work_keys_str_mv	AT ahmadamannan designinganirreversiblemetabolicswitchforscalableinductionofmicrobialchemicalproduction AT declangbates designinganirreversiblemetabolicswitchforscalableinductionofmicrobialchemicalproduction
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Designing an irreversible metabolic switch for scalable induction of microbial chemical production

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