Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury

Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury

Abstract Ischemia–reperfusion injury impairs the efficacy of reperfusion therapy after ischemic stroke. Cyclophilin D (CypD)-mediated openings of mitochondrial permeability transition pore (mPTP) and subsequent monocyte-mediated inflammation are considered as major mechanisms of reperfusion injury....

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Autores principales: Arihide Okahara, Jun-ichiro Koga, Tetsuya Matoba, Masaki Fujiwara, Masaki Tokutome, Gentaro Ikeda, Kaku Nakano, Masaki Tachibana, Tetsuro Ago, Takanari Kitazono, Hiroyuki Tsutsui, Kensuke Egashira
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/929409dd3f8a48648a7dd82691a4b1ce
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