Disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from 18F-FDG PET brain persistent homology network
Abstract Dementia is related to the cellular accumulation of β-amyloid plaques, tau aggregates, or α-synuclein aggregates, or to neurotransmitter deficiencies in the dopaminergic and cholinergic pathways. Cellular and neurochemical changes are both involved in dementia pathology. However, the role o...
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Main Authors: | Tun-Wei Hsu, Jong-Ling Fuh, Da-Wei Wang, Li-Fen Chen, Chia-Jung Chang, Wen-Sheng Huang, Hsiu-Mei Wu, Wan-Yuo Guo |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Online Access: | https://doaj.org/article/92a1a544d3d8466c8e8172363f08a084 |
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