Protein C inhibitor--a novel antimicrobial agent.

Protein C inhibitor (PCI) is a heparin-binding serine proteinase inhibitor belonging to the family of serpin proteins. Here we describe that PCI exerts broad antimicrobial activity against bacterial pathogens. This ability is mediated by the interaction of PCI with lipid membranes, which subsequentl...

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Auteurs principaux: Erik Malmström, Matthias Mörgelin, Martin Malmsten, Linda Johansson, Anna Norrby-Teglund, Oonagh Shannon, Artur Schmidtchen, Joost C M Meijers, Heiko Herwald
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2009
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Accès en ligne:https://doaj.org/article/92aabe1548634f01850a5eaa25f6ec90
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