TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival

Interleukin-15 (IL-15) regulates the homeostasis of many immune cell types, including natural killer T (NKT) cells, but the underlying mechanism is not completely clear. Here the authors analyse Tbkbp1-deficient mice and show that IL-15 induces Tbkbp1-dependent autophagy to modulate NKT survival.

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Autores principales:	Lele Zhu, Xiaoping Xie, Lingyun Zhang, Hui Wang, Zuliang Jie, Xiaofei Zhou, Jianhong Shi, Shuli Zhao, Boxiang Zhang, Xuhong Cheng, Shao-Cong Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92aecf591e844ff9a8cf1378b35aec46
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spelling	oai:doaj.org-article:92aecf591e844ff9a8cf1378b35aec462021-12-02T14:41:16ZTBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival10.1038/s41467-018-05097-52041-1723https://doaj.org/article/92aecf591e844ff9a8cf1378b35aec462018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05097-5https://doaj.org/toc/2041-1723Interleukin-15 (IL-15) regulates the homeostasis of many immune cell types, including natural killer T (NKT) cells, but the underlying mechanism is not completely clear. Here the authors analyse Tbkbp1-deficient mice and show that IL-15 induces Tbkbp1-dependent autophagy to modulate NKT survival.Lele ZhuXiaoping XieLingyun ZhangHui WangZuliang JieXiaofei ZhouJianhong ShiShuli ZhaoBoxiang ZhangXuhong ChengShao-Cong SunNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lele Zhu Xiaoping Xie Lingyun Zhang Hui Wang Zuliang Jie Xiaofei Zhou Jianhong Shi Shuli Zhao Boxiang Zhang Xuhong Cheng Shao-Cong Sun TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
description	Interleukin-15 (IL-15) regulates the homeostasis of many immune cell types, including natural killer T (NKT) cells, but the underlying mechanism is not completely clear. Here the authors analyse Tbkbp1-deficient mice and show that IL-15 induces Tbkbp1-dependent autophagy to modulate NKT survival.
format	article
author	Lele Zhu Xiaoping Xie Lingyun Zhang Hui Wang Zuliang Jie Xiaofei Zhou Jianhong Shi Shuli Zhao Boxiang Zhang Xuhong Cheng Shao-Cong Sun
author_facet	Lele Zhu Xiaoping Xie Lingyun Zhang Hui Wang Zuliang Jie Xiaofei Zhou Jianhong Shi Shuli Zhao Boxiang Zhang Xuhong Cheng Shao-Cong Sun
author_sort	Lele Zhu
title	TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
title_short	TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
title_full	TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
title_fullStr	TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
title_full_unstemmed	TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival
title_sort	tbk-binding protein 1 regulates il-15-induced autophagy and nkt cell survival
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/92aecf591e844ff9a8cf1378b35aec46
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_version_	1718389945147588608

TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival

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