Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

Fanconi anemia is a rare disease caused by defective DNA interstrand crosslink repair. Here the authors observe that USP48 deficiencies reduce chromosomal instability in FA-defective cells, suggesting it might be a potential therapeutic target.

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Autores principales:	Georgia Velimezi, Lydia Robinson-Garcia, Francisco Muñoz-Martínez, Wouter W. Wiegant, Joana Ferreira da Silva, Michel Owusu, Martin Moder, Marc Wiedner, Sara Brin Rosenthal, Kathleen M. Fisch, Jason Moffat, Jörg Menche, Haico van Attikum, Stephen P. Jackson, Joanna I. Loizou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92ba886efa2648b7b1f7f3b80505b1ec
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spelling	oai:doaj.org-article:92ba886efa2648b7b1f7f3b80505b1ec2021-12-02T14:39:22ZMap of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP4810.1038/s41467-018-04649-z2041-1723https://doaj.org/article/92ba886efa2648b7b1f7f3b80505b1ec2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04649-zhttps://doaj.org/toc/2041-1723Fanconi anemia is a rare disease caused by defective DNA interstrand crosslink repair. Here the authors observe that USP48 deficiencies reduce chromosomal instability in FA-defective cells, suggesting it might be a potential therapeutic target.Georgia VelimeziLydia Robinson-GarciaFrancisco Muñoz-MartínezWouter W. WiegantJoana Ferreira da SilvaMichel OwusuMartin ModerMarc WiednerSara Brin RosenthalKathleen M. FischJason MoffatJörg MencheHaico van AttikumStephen P. JacksonJoanna I. LoizouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Georgia Velimezi Lydia Robinson-Garcia Francisco Muñoz-Martínez Wouter W. Wiegant Joana Ferreira da Silva Michel Owusu Martin Moder Marc Wiedner Sara Brin Rosenthal Kathleen M. Fisch Jason Moffat Jörg Menche Haico van Attikum Stephen P. Jackson Joanna I. Loizou Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
description	Fanconi anemia is a rare disease caused by defective DNA interstrand crosslink repair. Here the authors observe that USP48 deficiencies reduce chromosomal instability in FA-defective cells, suggesting it might be a potential therapeutic target.
format	article
author	Georgia Velimezi Lydia Robinson-Garcia Francisco Muñoz-Martínez Wouter W. Wiegant Joana Ferreira da Silva Michel Owusu Martin Moder Marc Wiedner Sara Brin Rosenthal Kathleen M. Fisch Jason Moffat Jörg Menche Haico van Attikum Stephen P. Jackson Joanna I. Loizou
author_facet	Georgia Velimezi Lydia Robinson-Garcia Francisco Muñoz-Martínez Wouter W. Wiegant Joana Ferreira da Silva Michel Owusu Martin Moder Marc Wiedner Sara Brin Rosenthal Kathleen M. Fisch Jason Moffat Jörg Menche Haico van Attikum Stephen P. Jackson Joanna I. Loizou
author_sort	Georgia Velimezi
title	Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
title_short	Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
title_full	Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
title_fullStr	Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
title_full_unstemmed	Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
title_sort	map of synthetic rescue interactions for the fanconi anemia dna repair pathway identifies usp48
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/92ba886efa2648b7b1f7f3b80505b1ec
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Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

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