Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

Atypical antipsychotics show reduced extrapyramidal side effects compared to first generation drugs. Here the authors use time-resolved FRET to measure binding kinetics, and show that side effects correlate with drug association rates to the D2 receptor, while dissociation rates correlate with prola...

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Autores principales:	David A. Sykes, Holly Moore, Lisa Stott, Nicholas Holliday, Jonathan A. Javitch, J. Robert Lane, Steven J. Charlton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92ce2e6b0c464f92849b40c8f8648e24
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spelling	oai:doaj.org-article:92ce2e6b0c464f92849b40c8f8648e242021-12-02T14:40:59ZExtrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors10.1038/s41467-017-00716-z2041-1723https://doaj.org/article/92ce2e6b0c464f92849b40c8f8648e242017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00716-zhttps://doaj.org/toc/2041-1723Atypical antipsychotics show reduced extrapyramidal side effects compared to first generation drugs. Here the authors use time-resolved FRET to measure binding kinetics, and show that side effects correlate with drug association rates to the D2 receptor, while dissociation rates correlate with prolactin elevation.David A. SykesHolly MooreLisa StottNicholas HollidayJonathan A. JavitchJ. Robert LaneSteven J. CharltonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David A. Sykes Holly Moore Lisa Stott Nicholas Holliday Jonathan A. Javitch J. Robert Lane Steven J. Charlton Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
description	Atypical antipsychotics show reduced extrapyramidal side effects compared to first generation drugs. Here the authors use time-resolved FRET to measure binding kinetics, and show that side effects correlate with drug association rates to the D2 receptor, while dissociation rates correlate with prolactin elevation.
format	article
author	David A. Sykes Holly Moore Lisa Stott Nicholas Holliday Jonathan A. Javitch J. Robert Lane Steven J. Charlton
author_facet	David A. Sykes Holly Moore Lisa Stott Nicholas Holliday Jonathan A. Javitch J. Robert Lane Steven J. Charlton
author_sort	David A. Sykes
title	Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
title_short	Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
title_full	Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
title_fullStr	Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
title_full_unstemmed	Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
title_sort	extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine d2 receptors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/92ce2e6b0c464f92849b40c8f8648e24
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Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

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