Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation

Germline cells transfer genetic information to offspring, and in zebrafish, drive sex determination. Here the authors report that, unlike mammals, the germline of zebrafish does not undergo genome-wide DNA methylation erasure, while amplifying and demethylating sex-linked rDNA during feminisation.

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Autores principales:	Oscar Ortega-Recalde, Robert C. Day, Neil J. Gemmell, Timothy A. Hore
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/930144fede1144be9a981b3a57912b2a
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spelling	oai:doaj.org-article:930144fede1144be9a981b3a57912b2a2021-12-02T14:40:18ZZebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation10.1038/s41467-019-10894-72041-1723https://doaj.org/article/930144fede1144be9a981b3a57912b2a2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10894-7https://doaj.org/toc/2041-1723Germline cells transfer genetic information to offspring, and in zebrafish, drive sex determination. Here the authors report that, unlike mammals, the germline of zebrafish does not undergo genome-wide DNA methylation erasure, while amplifying and demethylating sex-linked rDNA during feminisation.Oscar Ortega-RecaldeRobert C. DayNeil J. GemmellTimothy A. HoreNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oscar Ortega-Recalde Robert C. Day Neil J. Gemmell Timothy A. Hore Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
description	Germline cells transfer genetic information to offspring, and in zebrafish, drive sex determination. Here the authors report that, unlike mammals, the germline of zebrafish does not undergo genome-wide DNA methylation erasure, while amplifying and demethylating sex-linked rDNA during feminisation.
format	article
author	Oscar Ortega-Recalde Robert C. Day Neil J. Gemmell Timothy A. Hore
author_facet	Oscar Ortega-Recalde Robert C. Day Neil J. Gemmell Timothy A. Hore
author_sort	Oscar Ortega-Recalde
title	Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
title_short	Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
title_full	Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
title_fullStr	Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
title_full_unstemmed	Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation
title_sort	zebrafish preserve global germline dna methylation while sex-linked rdna is amplified and demethylated during feminisation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/930144fede1144be9a981b3a57912b2a
work_keys_str_mv	AT oscarortegarecalde zebrafishpreserveglobalgermlinednamethylationwhilesexlinkedrdnaisamplifiedanddemethylatedduringfeminisation AT robertcday zebrafishpreserveglobalgermlinednamethylationwhilesexlinkedrdnaisamplifiedanddemethylatedduringfeminisation AT neiljgemmell zebrafishpreserveglobalgermlinednamethylationwhilesexlinkedrdnaisamplifiedanddemethylatedduringfeminisation AT timothyahore zebrafishpreserveglobalgermlinednamethylationwhilesexlinkedrdnaisamplifiedanddemethylatedduringfeminisation
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Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation

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