Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity

Abstract Chondrosarcoma is a malignant primary bone tumor. Sirtuin-1 (SIRT1), which is a member of sirtuin family, plays a dual role either in cancer promotion or suppression. There is no report about the role of SIRT1 in the human chondrosarcoma cells. Resveratrol is a potent activator of SIRT1. Ho...

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Main Authors: Sung-Chuan Chao, Ying-Ju Chen, Kuo-How Huang, Kuan-Lin Kuo, Ting-Hua Yang, Kuo-Yuan Huang, Ching-Chia Wang, Chih-Hsin Tang, Rong-Sen Yang, Shing-Hwa Liu
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
R
Q
Online Access:https://doaj.org/article/9306eebba13941fc858fee73c7c66b17
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