Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons

Astrocyte in the brain regulates synaptic transmission by releasing gliotransmitters. Here, Tan and colleagues use optogenetic stimulation of astrocytes to show differential neuronal subtype-specific purinoceptor responses to astrocytic ATP release to affect network excitability.

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Autores principales: Zhibing Tan, Yu Liu, Wang Xi, Hui-fang Lou, Liya Zhu, Zhifei Guo, Lin Mei, Shumin Duan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/938970f39c4243aea675e30a2ba9ce40
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spelling oai:doaj.org-article:938970f39c4243aea675e30a2ba9ce402021-12-02T17:06:04ZGlia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons10.1038/ncomms137722041-1723https://doaj.org/article/938970f39c4243aea675e30a2ba9ce402017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13772https://doaj.org/toc/2041-1723Astrocyte in the brain regulates synaptic transmission by releasing gliotransmitters. Here, Tan and colleagues use optogenetic stimulation of astrocytes to show differential neuronal subtype-specific purinoceptor responses to astrocytic ATP release to affect network excitability.Zhibing TanYu LiuWang XiHui-fang LouLiya ZhuZhifei GuoLin MeiShumin DuanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhibing Tan
Yu Liu
Wang Xi
Hui-fang Lou
Liya Zhu
Zhifei Guo
Lin Mei
Shumin Duan
Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons
description Astrocyte in the brain regulates synaptic transmission by releasing gliotransmitters. Here, Tan and colleagues use optogenetic stimulation of astrocytes to show differential neuronal subtype-specific purinoceptor responses to astrocytic ATP release to affect network excitability.
format article
author Zhibing Tan
Yu Liu
Wang Xi
Hui-fang Lou
Liya Zhu
Zhifei Guo
Lin Mei
Shumin Duan
author_facet Zhibing Tan
Yu Liu
Wang Xi
Hui-fang Lou
Liya Zhu
Zhifei Guo
Lin Mei
Shumin Duan
author_sort Zhibing Tan
title Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons
title_short Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons
title_full Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons
title_fullStr Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons
title_full_unstemmed Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons
title_sort glia-derived atp inversely regulates excitability of pyramidal and cck-positive neurons
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/938970f39c4243aea675e30a2ba9ce40
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