Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis

The visualisation of the bone metastasis process in a spatial temporal manner is lacking. Here, the authors use three-dimensional quantitative imaging and show that mouse mammary tumour cells preferentially home to endothelial subtype type H vessels within the bone marrow and remodel this vasculatur...

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Autores principales:	Raymond K. H. Yip, Joel S. Rimes, Bianca D. Capaldo, François Vaillant, Kellie A. Mouchemore, Bhupinder Pal, Yunshun Chen, Elliot Surgenor, Andrew J. Murphy, Robin L. Anderson, Gordon K. Smyth, Geoffrey J. Lindeman, Edwin D. Hawkins, Jane E. Visvader
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/938d0b41436b4974bba32259f0e9856a
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spelling	oai:doaj.org-article:938d0b41436b4974bba32259f0e9856a2021-11-28T12:33:59ZMammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis10.1038/s41467-021-26556-62041-1723https://doaj.org/article/938d0b41436b4974bba32259f0e9856a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26556-6https://doaj.org/toc/2041-1723The visualisation of the bone metastasis process in a spatial temporal manner is lacking. Here, the authors use three-dimensional quantitative imaging and show that mouse mammary tumour cells preferentially home to endothelial subtype type H vessels within the bone marrow and remodel this vasculature by producing granulocyte-colony stimulating factor.Raymond K. H. YipJoel S. RimesBianca D. CapaldoFrançois VaillantKellie A. MouchemoreBhupinder PalYunshun ChenElliot SurgenorAndrew J. MurphyRobin L. AndersonGordon K. SmythGeoffrey J. LindemanEdwin D. HawkinsJane E. VisvaderNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raymond K. H. Yip Joel S. Rimes Bianca D. Capaldo François Vaillant Kellie A. Mouchemore Bhupinder Pal Yunshun Chen Elliot Surgenor Andrew J. Murphy Robin L. Anderson Gordon K. Smyth Geoffrey J. Lindeman Edwin D. Hawkins Jane E. Visvader Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis
description	The visualisation of the bone metastasis process in a spatial temporal manner is lacking. Here, the authors use three-dimensional quantitative imaging and show that mouse mammary tumour cells preferentially home to endothelial subtype type H vessels within the bone marrow and remodel this vasculature by producing granulocyte-colony stimulating factor.
format	article
author	Raymond K. H. Yip Joel S. Rimes Bianca D. Capaldo François Vaillant Kellie A. Mouchemore Bhupinder Pal Yunshun Chen Elliot Surgenor Andrew J. Murphy Robin L. Anderson Gordon K. Smyth Geoffrey J. Lindeman Edwin D. Hawkins Jane E. Visvader
author_facet	Raymond K. H. Yip Joel S. Rimes Bianca D. Capaldo François Vaillant Kellie A. Mouchemore Bhupinder Pal Yunshun Chen Elliot Surgenor Andrew J. Murphy Robin L. Anderson Gordon K. Smyth Geoffrey J. Lindeman Edwin D. Hawkins Jane E. Visvader
author_sort	Raymond K. H. Yip
title	Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis
title_short	Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis
title_full	Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis
title_fullStr	Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis
title_full_unstemmed	Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis
title_sort	mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/938d0b41436b4974bba32259f0e9856a
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Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis

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