Our Exciting Journey to ACT-451840

We describe our work resulting in the selection of ACT-451840 ( 38 ) as a novel antimalarial drug with a novel mode of action. The compound was broadly characterized in vitro as well as in vivo in rat PK experiments as well as two different mouse malaria models. In the P. berghei infected mouse mode...

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Autores principales: Christoph Boss, Sergio Wittlin
Formato: article
Lenguaje:DE
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Publicado: Swiss Chemical Society 2021
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Acceso en línea:https://doaj.org/article/93b7c702dfa74ab3aef04287a807090c
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