A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration
Myocardial regeneration and proliferation of heart muscle cells is limited to a short period after birth early postnatal life, after which heart muscle cells can only grow in size and not in number. Here, the authors identified that the expression level of an endogenous microRNA cluster in heart mus...
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Nature Portfolio
2021
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oai:doaj.org-article:940312e06d484466827c2f7aaaa0a4ae2021-12-02T18:50:59ZA microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration10.1038/s41467-021-25211-42041-1723https://doaj.org/article/940312e06d484466827c2f7aaaa0a4ae2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25211-4https://doaj.org/toc/2041-1723Myocardial regeneration and proliferation of heart muscle cells is limited to a short period after birth early postnatal life, after which heart muscle cells can only grow in size and not in number. Here, the authors identified that the expression level of an endogenous microRNA cluster in heart muscle promotes the passage of the proliferative state to adult heart growth, and modulating the expression of this cluster can stimulate heart regeneration after myocardial infarction.Andrea RasoEllen DirkxVasco Sampaio-PintoHamid el AzzouziRyan J. CuberoDaniel W. SorensenLara OttavianiServé OlieslagersManon M. HuibersRoel de WegerSailay SiddiqiSilvia MoimasConsuelo TorriniLorena ZentillinLuca BragaDiana S. NascimentoPaula A. da Costa MartinsJop H. van BerloSerena ZacchignaMauro GiaccaLeon J. De WindtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Andrea Raso Ellen Dirkx Vasco Sampaio-Pinto Hamid el Azzouzi Ryan J. Cubero Daniel W. Sorensen Lara Ottaviani Servé Olieslagers Manon M. Huibers Roel de Weger Sailay Siddiqi Silvia Moimas Consuelo Torrini Lorena Zentillin Luca Braga Diana S. Nascimento Paula A. da Costa Martins Jop H. van Berlo Serena Zacchigna Mauro Giacca Leon J. De Windt A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration |
| description |
Myocardial regeneration and proliferation of heart muscle cells is limited to a short period after birth early postnatal life, after which heart muscle cells can only grow in size and not in number. Here, the authors identified that the expression level of an endogenous microRNA cluster in heart muscle promotes the passage of the proliferative state to adult heart growth, and modulating the expression of this cluster can stimulate heart regeneration after myocardial infarction. |
| format |
article |
| author |
Andrea Raso Ellen Dirkx Vasco Sampaio-Pinto Hamid el Azzouzi Ryan J. Cubero Daniel W. Sorensen Lara Ottaviani Servé Olieslagers Manon M. Huibers Roel de Weger Sailay Siddiqi Silvia Moimas Consuelo Torrini Lorena Zentillin Luca Braga Diana S. Nascimento Paula A. da Costa Martins Jop H. van Berlo Serena Zacchigna Mauro Giacca Leon J. De Windt |
| author_facet |
Andrea Raso Ellen Dirkx Vasco Sampaio-Pinto Hamid el Azzouzi Ryan J. Cubero Daniel W. Sorensen Lara Ottaviani Servé Olieslagers Manon M. Huibers Roel de Weger Sailay Siddiqi Silvia Moimas Consuelo Torrini Lorena Zentillin Luca Braga Diana S. Nascimento Paula A. da Costa Martins Jop H. van Berlo Serena Zacchigna Mauro Giacca Leon J. De Windt |
| author_sort |
Andrea Raso |
| title |
A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration |
| title_short |
A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration |
| title_full |
A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration |
| title_fullStr |
A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration |
| title_full_unstemmed |
A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration |
| title_sort |
microrna program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/940312e06d484466827c2f7aaaa0a4ae |
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