Large enhancement of response times of a protein conformational switch by computational design

The rational optimization of response times of protein conformational switches is a major challenge for biomolecular switch design. Here the authors present a generally applicable computational design strategy that in combination with biophysical experiments can improve response times using a Ca2+-s...

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Autores principales:	Alex J. DeGrave, Jeung-Hoi Ha, Stewart N. Loh, Lillian T. Chong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/94220e635e4c46a6835d838c064d7ecc
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spelling	oai:doaj.org-article:94220e635e4c46a6835d838c064d7ecc2021-12-02T16:50:10ZLarge enhancement of response times of a protein conformational switch by computational design10.1038/s41467-018-03228-62041-1723https://doaj.org/article/94220e635e4c46a6835d838c064d7ecc2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03228-6https://doaj.org/toc/2041-1723The rational optimization of response times of protein conformational switches is a major challenge for biomolecular switch design. Here the authors present a generally applicable computational design strategy that in combination with biophysical experiments can improve response times using a Ca2+-sensor as an example.Alex J. DeGraveJeung-Hoi HaStewart N. LohLillian T. ChongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alex J. DeGrave Jeung-Hoi Ha Stewart N. Loh Lillian T. Chong Large enhancement of response times of a protein conformational switch by computational design
description	The rational optimization of response times of protein conformational switches is a major challenge for biomolecular switch design. Here the authors present a generally applicable computational design strategy that in combination with biophysical experiments can improve response times using a Ca2+-sensor as an example.
format	article
author	Alex J. DeGrave Jeung-Hoi Ha Stewart N. Loh Lillian T. Chong
author_facet	Alex J. DeGrave Jeung-Hoi Ha Stewart N. Loh Lillian T. Chong
author_sort	Alex J. DeGrave
title	Large enhancement of response times of a protein conformational switch by computational design
title_short	Large enhancement of response times of a protein conformational switch by computational design
title_full	Large enhancement of response times of a protein conformational switch by computational design
title_fullStr	Large enhancement of response times of a protein conformational switch by computational design
title_full_unstemmed	Large enhancement of response times of a protein conformational switch by computational design
title_sort	large enhancement of response times of a protein conformational switch by computational design
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/94220e635e4c46a6835d838c064d7ecc
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_version_	1718383113596305408

Large enhancement of response times of a protein conformational switch by computational design

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