Large enhancement of response times of a protein conformational switch by computational design
The rational optimization of response times of protein conformational switches is a major challenge for biomolecular switch design. Here the authors present a generally applicable computational design strategy that in combination with biophysical experiments can improve response times using a Ca2+-s...
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Autores principales: | Alex J. DeGrave, Jeung-Hoi Ha, Stewart N. Loh, Lillian T. Chong |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/94220e635e4c46a6835d838c064d7ecc |
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