Large enhancement of response times of a protein conformational switch by computational design

The rational optimization of response times of protein conformational switches is a major challenge for biomolecular switch design. Here the authors present a generally applicable computational design strategy that in combination with biophysical experiments can improve response times using a Ca2+-s...

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Autores principales: Alex J. DeGrave, Jeung-Hoi Ha, Stewart N. Loh, Lillian T. Chong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/94220e635e4c46a6835d838c064d7ecc
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